Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is a form of chronic pain that usually affects an arm or a leg. CRPS typically develops after an injury, a surgery, a stroke or a heart attack. The pain is out of proportion to the severity of the initial injury.

CRPS is uncommon, and its cause isn’t clearly understood. Treatment is most effective when started early. In such cases, improvement and even remission are possible.

SYMPTOMS

Signs and symptoms of CRPS include:

• Continuous burning or throbbing pain, usually in your arm, leg, hand or foot
• Sensitivity to touch or cold
• Swelling of the painful area
• Changes in skin temperature — alternating between sweaty and cold
• Changes in skin color, ranging from white and blotchy to red or blue
• Changes in skin texture, which may become tender, thin or shiny in the affected area
• Changes in hair and nail growth
• Joint stiffness, swelling and damage
• Muscle spasms, tremors, weakness and loss (atrophy)
• Decreased ability to move the affected body part

Symptoms may change over time and vary from person to person. Pain, swelling, redness, noticeable changes in temperature and hypersensitivity (particularly to cold and touch) usually occur first.

Symptoms may change over time and vary from person to person. Pain, swelling, redness, noticeable changes in temperature and hypersensitivity (particularly to cold and touch) usually occur first.

Over time, the affected limb can become cold and pale. It may undergo skin and nail changes as well as muscle spasms and tightening. Once these changes occur, the condition is often irreversible.

CRPS occasionally may spread from its source to elsewhere in your body, such as the opposite limb.

In some people, signs and symptoms of CRPS go away on their own. In others, signs and symptoms may persist for months to years. Treatment is likely to be most effective when started early in the course of the illness.

CAUSES

The cause of CRPS isn’t completely understood. It’s thought to be caused by an injury to or an abnormality of the peripheral and central nervous systems. CRPS typically occurs as a result of a trauma or an injury.

CRPS occurs in two types, with similar signs and symptoms, but different causes:

• Type 1 Also known as reflex sympathetic dystrophy (RSD), this type occurs after an illness or injury that didn’t directly damage the nerves in your affected limb. About 90% of people with CRPS have type 1.
• Type 2 Once referred to as causalgia, this type has symptoms similar to those of type 1. But type 2 CRPS occurs after a distinct nerve injury.

Many cases of CRPS occur after a forceful trauma to an arm or a leg. This can include a crushing injury or a fracture.

Other major and minor traumas — such as surgery, heart attacks, infections and even sprained ankles — also can lead to CRPS.

It’s not well understood why these injuries can trigger CRPS. Not everyone who has such an injury will go on to develop CRPS. It might be due to a dysfunctional interaction between your central and peripheral nervous systems and inappropriate inflammatory responses.

COMPLICATIONS

• Tissue wasting (atrophy). Your skin, bones and muscles may begin to deteriorate and weaken if you avoid or have trouble moving an arm or a leg because of pain or stiffness.
• Muscle tightening (contracture). You also may experience tightening of your muscles. This may lead to a condition in which your hand and fingers or your foot and toes contract into a fixed position.

DIAGNOSIS

Diagnosis of CRPS is based on a physical exam and your medical history. There’s no single test that can definitively diagnose CRPS, but the following procedures may provide important clues:

• Bone scan- This procedure might help find bone changes. A radioactive substance injected into one of your veins allows your bones to be seen with a special camera.
• Nerve conduction test- Some tests can measure working or non-working of nerve
• X-rays- Loss of minerals from your bones may show up on an X-ray in later stages of the disease.
• Magnetic resonance imaging (MRI) Images captured with an MRI test may show tissue changes that rule out other conditions.

TREATMENT

There’s some evidence that early treatment might help improve symptoms of CRPS. Often, a combination of different treatments, tailored to your specific case, is necessary. Treatment options include:There’s some evidence that early treatment might help improve symptoms of CRPS. Often, a combination of different treatments, tailored to your specific case, is necessary. Treatment options include:

MEDICATION

Doctors use various medications to treat the symptoms of CRPS.

• Pain relievers pain relievers — such as aspirin, ibuprofen and naproxen sodium — may ease mild pain and inflammation.Your doctor may prescribe stronger pain relievers if OTC ones aren’t helpful. Opioid medications might be an option. Taken in appropriate doses, they might help control pain.
• Antidepressants and anticonvulsants Sometimes antidepressants, such as amitriptyline, and anticonvulsants, such as gabapentin, are used to treat pain that originates from a damaged nerve (neuropathic pain).
• Corticosteroids Steroid medications, such as prednisone, may reduce inflammation and improve mobility in the affected limb.
• Bone-loss medications Your doctor may suggest medications to prevent or stall bone loss, such as alendronate and calcitonin.
• Sympathetic nerve-blocking medication Injection of an anaesthetic to block pain fibres in the affected nerves may relieve pain in some people. Pulsed radiofrequency or conventional radiofrequency ablation may be helpful in few patients.
• Intravenous ketamine- Some studies show that low doses of intravenous ketamine, a strong anaesthetic, may substantially alleviate pain.

THERAPIES

Heat therapy Applying heat may offer relief of swelling and discomfort on skin that feels cool.

Topical analgesics Various topical treatments are available that may reduce hypersensitivity, such as over-the-counter capsaicin cream, or lidocaine cream or patches.

Physical or occupational therapy Gentle, guided exercising of the affected limbs or modifying daily activities might help decrease pain and improve range of motion and strength. The earlier the disease is diagnosed; the more effective exercises might be.

Transcutaneous electrical nerve stimulation (TENS) Chronic pain is sometimes eased by applying electrical impulses to nerve endings.

Biofeedback In some cases, learning biofeedback techniques may help. In biofeedback, you learn to become more aware of your body so that you can relax your body and relieve pain.

Spinal cord stimulation at DR YUVRAJ PAIN CLINIC we are doing spinal cord stimulator to treat CRPS (Complex regional pain Syndrome). In this procedure we insert tiny electrodes along your spinal cord. A small electrical current delivered to the spinal cord results in pain relief.

Intrathecal drug pumps At DR YUVRAJ PAIN CLINIC we are doing intrathecal pump to treat CRPS (Complex regional pain Syndrome). In this therapy, medications that relieve pain are pumped into the spinal cord fluid.